Page 105 - 北京京煤集团总医院第十一届·2023学术年会论文集

北京京煤集团总医院 第十一届·2023 学术年会论文集

碳酸氢钠片对冠脉造影后肾脏保护作用的研究

王鹏，刘安恒，罗建平，石红坡，郭勍（北京京煤集团总医院，北京 102300）

【摘要】目的：探索冠心病合并轻中度肾功能不全患者冠脉造影检查围手术期接受口服碳酸
氢钠片联合水化治疗对造影剂肾病 CIN(Contrast induced nephropathy)是否有预防作用。方法：

选取 2020 年 06 月～2022 年 12 月本院收治的合并轻中度肾功能不全的冠心病患者共 100
例。随机分为 2 组：A 组围手术期给予水化联合口服碳酸氢钠片治疗，B 组单纯水化治疗。

两组水化治疗速度均为 1ml/（kg·min）。 结果：两组患者均成功完成手术，两组患者在性别、
年龄、术前血肌酐水平、造影剂用量均无统计学差异。最终 A 组 46 例患者无 CIN 发生，B

组 54 例患者 8 例发生 CIN，其中 A 组、B 组 CIN 发生率分别为 0%、14%（P＝0.019），有

统计学差异。结论：围手术期给予碳酸氢钠片联合水化治疗对肾功能有保护作用，可以预防
造影剂肾病的发生。

【关键词】碳酸氢钠片；冠脉造影；肾功能不全；造影剂肾病
Study on renal protection of sodium bicarbonate tablets after coronary angiography
Wang peng，Liu an heng，Luo jian ping，Shi hong po，Guo qing

Beijing Jingmei Group General Hospital，Beijing 102300，China
[Abstract] Objective To explore whether oral sodium bicarbonate tablets combined with hydration

treatment during perioperative period has the preventive effect on CIN(Contrast induced
nephropathy) in patients with coronary heart disease complicated with mild to moderate renal
insufficiency by coronary angiography. Methods A total of 100 coronary heart disease patients with

mild to moderate renal insufficiency admitted to our hospital from June 2020 to December 2022
were selected. They were randomly divided into 2 groups: Group A was treated with hydration
combined with oral sodium bicarbonate tablets during perioperative period, group B was treated
with hydration alone. The hydration treatment rate in both groups was 1ml/ (kg·min). Results All
patients in the two groups successfully completed the operation, and there were no statistical

differences between the two groups in gender, age, preoperative serum creatinine level and contrast
agent dosage. In the end, 46 patients in group A had no CIN, and 8 patients in group B had CIN,
among which the incidence of CIN in group A and Group B were 0% and 14% respectively (P =

0.019), showing statistical difference. Conclusion Perioperative administration of sodium
bicarbonate tablets combined with hydration therapy has a protective effect on renal function and
can prevent the occurrence of contrast nephropathy.
[Key words] Sodium Bicarbonate Tablets；coronary angiogram；renal insufficiency；radiographic

contrast nephropathy
冠心病已成为危害我国人民生命健康的大敌。目前冠状动脉造影是诊断冠状动脉粥样硬

化性心脏病的一种常用而且有效的方法。现已广泛应用于临床，被认为是诊断冠心病的“金
标准”。冠脉造影技术的广泛应用造成造影剂的应用越来越普遍，随之导致造影剂肾病发病

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