Page 232 - 北京京煤集团总医院第十届·2022学术年会论文集

北京京煤集团总医院 第十届·2022 学术年会论文集

transcription factor
binding
transcription regulatory
(GO:0001067) region nucleic acid 0.003198684 TCF7L2;PER3;TAF7;PROX1;PO
U2F2;NFE2L2
binding
vitamin D receptor
(GO:0042809) 0.003902504 MED1;TAF7
binding
transcription cis- TCF7L2;PER3;TIPARP;ZBTB43;
(GO:0000976) regulatory region 0.004125991 TAF7;ZNF557;TCF3;PROX1;PO
binding U2F2;NFE2L2
nuclear receptor
(GO:0016922) 0.008925097 MED1;TCF7L2;TAF7;PROX1
binding
DNA-binding
(GO:0140297) transcription factor 0.013536357 TCF7L2;TCF3;CGGBP1;PIAS1;
NFE2L2
binding
thyroid hormone
(GO:0046966) 0.015241977 MED1;TAF7
receptor binding
ATXN2L;HSPA8;FASN;ARHGAP
(GO:0045296) cadherin binding 0.022195024
1;PLIN3;CCT8
Table 1:The top 10 GO terms in each category enriched by the overlapping DEGs.

Category Pathways P-values Genes

CAMK2B;KLC3;TUBA1B;NDUFB10;NDUFAB1;
KEGG Parkinson disease 0.006941853
NFE2L2
Diabetic
0.012292002 CAMK2B;NDUFB10;NDUFAB1;PTEN;PDHB
cardiomyopathy
Citrate cycle (TCA
0.017387345 PDHB;DLAT
cycle)
Spliceosome 0.018879044 HSPA8;SART1;SRSF1;SNRNP27

Amyotrophic lateral ATXN2L;KLC3;TUBA1B;NDUFB10;RB1CC1;ND
0.037181813
sclerosis UFAB1
Prion disease 0.037903587 HSPA8;KLC3;TUBA1B;NDUFB10;NDUFAB1

Pyruvate metabolism 0.040122723 PDHB;DLAT

Pathways of ATXN2L;CAMK2B;KLC3;TUBA1B;NDUFB10;R
0.042390458
neurodegeneration B1CC1;NDUFAB1
Table 2:KEGG pathways in each category enriched by the overlapping DEGPPI network

- 227 -