Page 236 - 北京京煤集团总医院第十届·2022学术年会论文集

北京京煤集团总医院 第十届·2022 学术年会论文集

Helveticoside 8.70E-07

Ouabain 9.12E-07

Bisacodyl 2.32E-06

Table 4 The top 10 drugs with the greatest potential of affecting the expression of the common

DEGs between COVID-19 and asthma

4. Discussion

Numerous studies have reported that asthma patients may have an increased risk of SARS-
CoV-2 infection and disease severity, and SARS-CoV-2 asthma patients have a wide range of

clinical manifestations [22, 23]. However, the underlying mechanisms of COVID-19 and asthma

remain unclear. Thus, in this study, we aimed to identify potential biomarkers for COVID-19 and

asthma. A total of 135 overlapped DEGs were obtained by determining the DEG intersection

between the GSE147507 and GSE143303 datasets, and these overlapped DEGs were significantly

enriched in eight KEGG pathways. The PPI network revealed that HSPA8, SRSF1, NDUFAB1,

PTEN, CCT8, HIST1H2BK, HIST2H2BE, DLAT, EIF3G, and WAC, with high scores, were the hub

genes. In addition, 65 TFs and 369 miRNAs were found to target overlapping DEGs. Finally, the

target drug and related diseases of the overlapped DEGs were predicted.

Based on GSE147507 and GSE143303 datasets, 135 overlapping DEGs were identified. These

135 genes may serve as potential markers of COVID-19 and asthma. In addition, enrichment

analysis was performed to analyze the mechanism of overlapping DEGs in COVID-19 and asthma.

The GOs results showed that the overlapping DEGs were enriched in regulating DNA-templated
transcription, initiation, clathrin-sculpted gamma-aminobutyric acid transport vesicle, and DNA

binding. KEGG pathways were enriched in Parkinson’s disease, diabetic cardiomyopathy, and the

citrate cycle (TCA cycle). Numerous studies have found that SARS-CoV-2 has direct or indirect

effects on Parkinson’s disease [24–26], and anti-Parkinson disease drugs may have protective or

harmful effects on severe COVID-19 prevention [27, 28]. Fasano et al. showed that frailty caused

by advanced Parkinson’s disease increases the risk of death during COVID-19 [29]. Cheng et al.

revealed that patients with asthma have a higher risk of Parkinson’s disease later in life [30]. SARS-

CoV-2 infection can cause cardiac complications [31]. Citrate is a vital substrate in cellular energy

metabolism, and evidence has shown that citrate is involved in inflammation, neurological disorders,

- 231 -