Page 237 - 北京京煤集团总医院第十届·2022学术年会论文集

北京京煤集团总医院 第十届·2022 学术年会论文集

and cancer [32]. Thus, this study suggests that the overlapping DEGs between COVID-19 and

asthma may play critical roles in COVID-19 and asthma through these pathways.

The PPI network was built to evaluate the protein–protein interactions between the overlapping
DEGs, with the top 10 genes being HSPA8, SRSF1, NDUFAB1, PTEN, CCT8, HIST1H2BK,

HIST2H2BE, DLAT, EIF3G, and WAC. Zhu et al. reported that HSPA8 is a novel host factor involved
in infectious bronchitis virus (IBV) infection [33]. Respiratory diseases in humans caused by IBV

and human respiratory pathology caused by SARS-CoV-2 share common characteristics [10, 34].

Jiang et al. found that SRSF1 is a common host factor that explores the intersection between asthma

and COVID-19 [35]. Sarma et al. observed that COVID-19 acute respiratory distress syndrome is

characterized by a dysregulated host response with increased PTEN signaling [36]. Wu et al. found

2+
that through CD38/Ca /CREB signaling, PTEN is involved in asthma airway remodeling [37].
Wang et al. found that CCT8 is associated with severe eosinophilic asthma [38]. However, few

studies of other hub genes in COVID-19 or asthma have been conducted, which might be novel

targets for COVID-19/asthma treatment.

TFs and miRNAs of overlapping DEGs were predicted, and 65 TFs and 369 miRNAs were

identified. In the TF–DEG interaction network, FOXC1 and GATA2 were regulated by many DEGs,
and hsa-miR-93-5p and hsa-miR-17-5p interacted with numerous DEGs. Liu et al. found that

miRNA-200a targets FOXC1 via the PI3K/AKT signaling pathway affected airway smooth muscle
cell proliferation and airway remodeling in ovalbumin-induced asthmatic mice [39]. Zhu et al.

revealed that isorhynchophylline exerts anti-asthma effects via upregulation of miR-200a in mice,

which then deactivates the FOXC1/NF-κB pathway [40]. Islam et al. also screened FOXC1 and

GATA2 as DEGs regulators in SARS-CoV-2 infected lung epithelial cells [41]. Samy et al. found

that hsa-miR-93-5p and hsa-miR-17-5p were blood markers of SARS-CoV-2 [42]. Nevertheless,

further in-depth studies are required.

These overlapping DEGs are also related to other diseases, such as hyperglycemia, metabolic

acidosis, and lung neoplasm. Among all the overlapping DEGs, ZMPSTE24 is related to most

diseases. Han et al. found that the decrease in ZMPSTE24 may increase vulnerability to SARS-CoV-

2 vascular endothelial damage with age and comorbidity [43]. Moreover, studies have reported that

digoxin and ouabain are resistant to SARS-CoV-2 [44]. Jamal et al. revealed that doxorubicin could

be a potential therapeutic agent against SARS-CoV-2 protease [45]. Chen et al. reported that

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