Page 76 - 北京京煤集团总医院第十届·2022学术年会论文集
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北京京煤集团总医院                                              第十届·2022 学术年会论文集


                   operating characteristic (ROC) curve was used to analyze the diagnostic value of RDW, MPV,

                   AMY and LPS for AP.    Results The levels of RDW, MPV, AMY and LPS in the AP group were

                   obviously higher than those in the control group (P<0.05); the Ranson score and the levels of RDW,
                   MPV, AMY and LPS in the SAP group were higher than those in the MAP group (P<0.05); the


                   levels of RDW, MPV, AMY and LPS in AP patients were positively correlated with the acute
                   pancreatitis severity estimate (Ranson) scores (r=0.281, 0.232, 0.303, 0.489,  P<0.05); the ROC

                   curve analysis results showed that the areas under the ROC curves (AUC ) of RDW, MPV, AMY

                   and LPS for the diagnosis of AP were 0.809, 0.793, 0.884, 0.893,respectively. Conclusion RDW,

                   MPV, AMY and LPS can serve as the diagnostic indicators for AP patients. As AP patients get

                   worse, the levels of RDW, MPV, AMY, LPS and the Ranson scores are increased significantly,

                   moreover the levels of RDW, MPV, AMY and LPS are positively correlated with the Ranson score.

                   Key words: Acute pancreatitis; Red blood cell volume distribution width; Average platelet volume;

                   Amylase; Lipase

                       急性胰腺炎(AP)是由多种病因激活胰酶,导致胰腺组织自身消化、水肿、出血甚至坏

                                      [1]
                   死的全身炎症性疾病 。AP 患者的临床表现主要为恶心、呕吐、急性上腹痛,更甚者出现
                   胰腺出血坏死、多器官衰竭,严重威胁患者的生命安全 。因此,早期准确诊断对 AP 的病
                                                                     [2]
                   情控制及预后改善起着重要的作用。有研究表明,红细胞体积分布宽度(RDW)、血小板平

                   均体积(MPV)、淀粉酶(AMY)及脂肪酶(LPS)水平与 AP 的病情发展密切相关                                  [3-5] 。 目
                   前,有关 RDW、MPV、AMY 及 LPS 对 AP 诊断价值的研究较少,本研究通过观察 RDW、

                   MPV、AMY 及 LPS 在处于不同疾病阶段 AP 患者中的水平,旨在探讨上述指标在 AP 诊断

                   及病情判断中的意义,以期为 AP 的临床诊断及病情判断提供依据,现报道如下。

                   1  资料与方法

                   1.1 一般资料

                       选取 2019 年 1 月至 2020 年 6 月北京京煤集团总医院收治的 100 例 AP 患者为 AP 组,

                   根据急性胰腺炎严重程度估计指标(Ranson 评分) 将                    AP 患者分为轻症急性胰腺炎(MAP)

                                                          [6]
                   组与重症急性胰腺炎(SAP)组。评估标准 :重度,≥3 分;轻度,<3 分。并选取同期健康
                   体检者 50 例为对照组。对照组:男 30 例,女 20 例;年龄 22~75 岁,平均(47.34±10.20)

                   岁。AP 组:男 58 例,女 42 例;年龄 20~78 岁,平均(48.33±12.56)岁;MAP 44 例,SAP

                   56 例。两组性别、年龄比较,差异无统计学意义(P>0.05) , 具有可比性。AP 组纳入标准:
                                                                     [7]
                   符合《中国急性胰腺炎诊治指南》中 AP 相关诊断标准 。排除标准:合并重要器官功能严

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