Page 13 - 北京京煤集团总医院第十一届·2023学术年会论文集

北京京煤集团总医院 第十一届·2023 学术年会论文集

We found that differentially expressed CRs are mainly involved in cell cycle pathways. Severe
asthma is characterized by proliferation of airway smooth muscle (ASM) [39] . Stimulation, including

growth factors and extracellular proteins, regulates mitosis, which in turn induces ASM cell
proliferation [40]. The patients included in this study were partially treated with ICS or oral
corticosteroids (OCS) in a previous study [17] . The anti-asthmatic approach described above is an
effective inhibitor of ASM cell proliferation. Corticosteroids inhibit the signaling pathways of cell

cycle progression [41] . Differentially expressed CRs have also been found to be involved in lysine
degradation. Lysine residues can increase pro-inflammatory factor activity and affect collagen
synthesis. Thus, lysine degradation can modulate airway inflammation and airway remodeling,
which are key pathogenic features of asthma [26] . Drugs that target lysine may be important in the

treatment of severe asthma.
CRs control chromatin structure and function by catalyzing and binding histone modifications
and are regulators of epigenetics [42] . Asthma patients were found to have enhanced histone
acetyltransferases activity and reduced histone deacetylases activity. These modifications may lead

to increased expression of genes associated with the inflammatory response profile of asthma [43] .
Another study related to differentially expressed chromatin-modifying enzymes found that cigarette
smoke differentially affected the expression of epigenetic regulators in patients with chronic

obstructive pulmonary disease, further regulating the expression of target genes [44] . This study is
the first to investigate the role of differentially expressed CRs in severe asthma, which may provide
new targets for the treatment of asthma in the future.
This study had some limitations. First, the sample size may not be sufficiently representative.

Second, the results were not experimentally validated. Moreover, multiple prospective studies are
still needed.
In conclusion, this study constructed a risk model with good predictive performance by
screening for differentially expressed CRs between subjects with severe asthma and healthy

individuals and by selecting hub CRs among them. The results of this study provide new insights
into the mechanisms underlying CRs in severe asthma.
Declarations：

Ethics approval and consent to participate：

GEO belong to public databases. The patients involved in the database have obtained ethical
approval. Users can download relevant data for free for research and publish relevant articles. Our
study is based on open source data, so there are no ethical issues and other conflicts of interest.
Consent for publication：

Not applicable.
Availability of data and materials：

The datasets GSE143303 for this study can be found in the GEO database Home-GEO-NCBI
(https://www.ncbi.nlm.nih.gov/geo/) .Data openly available in a public repository.
Competing of interest:

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