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北京京煤集团总医院 第十一届·2023 学术年会论文集
Figure 4: Gene interaction and immunity analyses. (A) Protein-protein interaction network of
differentially expressed chromatin regulators between patients with severe asthma and healthy
individuals. (B) Correlation among the ten top hub chromatin regulators in the protein-protein
interaction network with immune genes and immune functions.
These four genes, SMARCC1, SETD2, KMT2B, and CHD8, were used to construct a nomogram
model for predicting the prognosis of patients with severe asthma (Figure 5A). Furthermore, ROC
curves showed that the AUC of this model was 0.908, indicating a good predictive performance
(Figure 5B). The calibration curves showed that the model predictions and actual values were
generally consistent under ideal conditions (Figure 5C).
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