Page 8 - 北京京煤集团总医院第十一届·2023学术年会论文集

北京京煤集团总医院 第十一届·2023 学术年会论文集

Figure 1: Volcano plot of differentially expressed chromatin regulators between patients with severe

asthma and healthy individuals.
In addition, GO and KEGG analyses were performed to explore the potential functions and
pathways involved in the differential expression of CRs. GO analysis indicated that these genes
were mainly involved in histone modification, chromatin organization, peptidyl-lysine modification,

transcription regulator complex, and transcription coregulator activity (Figure 2A), and the enriched
pathways were lysine degradation and cell cycle (Figure 2B).

Figure 2: Enrichment analysis of differentially expressed chromatin regulators between patients
with severe asthma and healthy individuals. (A) Gene Ontology enrichment analysis. (B) Kyoto
Encyclopedia of Genes and Genomes-based pathway enrichment analysis. MF, molecular function;

BP, biological process; CC, cellular component.
3.2 Immune analysis of severe asthma
We compared the immune cell infiltration scores from patients with severe asthma and healthy
controls. The results showed that the scores for B cells, CD8+ T cells, iDCs, mast cells, NK cells, T

helper cells, and Th2 cells were significantly higher in healthy controls than in patients with severe

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