Page 120 - 北京京煤集团总医院第十届·2022学术年会论文集

北京京煤集团总医院 第十届·2022 学术年会论文集

雷公藤多苷片联合卡格列净治疗糖尿病肾病的临床效果

翟博娜，郝建荣（北京京煤集团总医院肾内科 102300）

【摘要】目的：探讨雷公藤多苷片联合卡格列净治疗糖尿病肾病（DN）的临床效果。方法：

选取 2020 年 1 月至 2021 年 6 月北京京煤集团总医院肾内科收治的 DN 患者 80 例作为研究
对象进行回顾性分析，根据不同治疗方式将其分为对照组（n=40）和观察组（n=40），对照

组采用卡格列净治疗，观察组采用卡格列净联合雷公藤多苷片治疗。比较两组患者治疗前后

的肾功能[24 h 尿蛋白定量（24-UP）、尿氮素（BUN）及血肌酐（SCr）]、肝功能[丙氨酸

转氨酶（ALT）、天冬氨酸转氨酶（AST）]及白细胞（WBC）。结果：治疗后，两组患者

的 24-UP、BUN 及 SCr 水平均低于治疗前，且观察组患者的 24-UP、BUN 及 SCr 均低于对

照组，差异有统计学意义（P＜0.05）。两组患者治疗前后 ALT、AST、WBC 组间及组内比

较，差异无统计学意义（P>0.05）。结论：雷公藤多苷片联合卡格列净治疗 DN 患者效果优

于单药卡格列净，对其肾功能有一定改善作用。

【关键词】 糖尿病肾病；雷公藤多苷片；卡格列净；临床疗效

Clinical effect of Tripterygium Glycoside Tablets combined with Canagliflozin in the

treatment of diabetic kidney disease

[Abstract] Objective To investigate the clinical effect of Tripterygium Glycoside Tablets combined

with Canagliflozin in the treatment of diabetic nephropathy (DN). Methods A total of 80 patients
with DN admitted to Department of Nephrology in Beijing Jingmei Group General Hospital from

January 2020 to June 2021 were selected as the research objects, and they were divided into the

control group (n=40) and the observation group (n=40) according to different treatment methods.

The retrospective analysis was used in this study. The control group was treated with Canagliflozin,

and the observation group was treated with Tripterygium Glycoside Tablets combined with

Canagliflozin. Both groups were treated for three months. The renal function (24-h quantitative of

urinary protein [24-UP], blood urea nitrogen [BUN], serum creatinine [SCr]), liver function (alanine

aminotransferase [ALT], aspartate aminotransferase [AST]) and white blood cell count (WBC)

before and after treatment were compared between the two groups. Results After treat- ment, the

levels of 24-UP, BUN and SCr in the two groups were lower than those before treatment, and the

levels of 24-UP, BUN and SCr in the observation group were lower than those in the control group,

and the differences were sta- tistically significant (P<0.05). There were no significant differences in

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