Page 177 - 北京京煤集团总医院第十届·2022学术年会论文集

北京京煤集团总医院 第十届·2022 学术年会论文集

control group were higher than those in the observation group, and the difference was statistically

significant (P<0.05). The triglyceride, low-density lipoprotein cholesterol and serum total

cholesterol in the observation group were higher than those in the control group, and the high-
density lipoprotein cholesterol and blood urea nitrogen in the observation group were lower than

those in the control group, and the difference was statistically significant(P<0.05). The triglyceride,
low-density lipoprotein cholesterol and serum total cholesterol in the observation group were higher

than those in the control group, and the high-density lipoprotein cholesterol and blood urea nitrogen

in the observation group were lower than those in the control group, and the difference was

statistically significant (P< 0.05). The boy pubic hair Tanner score, testis Tanner score, girl pubic

hair Tanner score and girl breast Tanner score of children with precocious puberty were significantly

higher than those of simple obesity children, and the difference was statistically significant (P<0.05).

Precocious puberty was positively correlated with fasting blood glucose, glycated hemoglobin, 2h

postprandial blood glucose, triglyceride, low-density lipoprotein cholesterol, and serum total

cholesterol in obese children, and negatively correlated with high-density lipoprotein cholesterol

and blood urea nitrogen, with statistically significant difference (P<0.05). Conclusion: There is a

correlation of blood lipid indexes and blood glucose indexes with the occurrence of precocious
puberty in obese children. Clinical screening of obese children should be done as soon as possible.

At the same time, health guidance should be taken to prevent the occurrence of precocious puberty
and promote the healthy growth and development of children.

Key words Obese children; Blood sugar; Blood lipid metabolism; Precocious puberty

中枢性性早熟是儿童阶段多发的性激素类疾病之一，发生于女孩8岁前、男孩9岁前，受

下丘脑-垂体-性腺轴功能异常影响引发该病；女童表现为 8 岁前出现第二性征发育( 乳腺增

大、成熟卵泡增大增多)， 或 10 岁前月经来潮；男童表现为＜9 岁出现性腺增大，同时表现

出第二性征。近年来，全球儿童肥胖的发病率呈逐年增高趋势，与此同时女童青春期启动时

间显著提前。相比于健康儿童来说，性早熟儿童的智力水平和心理水平相对较低，对儿童日

常生活产生了较为严重影响，干扰到其休息和学习。本研究以肥胖儿童为对象，分析其血糖

与血脂代谢特征，以及和性早熟之间存在的相关性，结果报告如下。

资料与方法

选取2019 年9 月-2021 年6 月在北京京煤集团总医院儿科就诊的肥胖儿童60例为观察

组，男32 例，女28 例；年龄6～11岁，平均(7.76±1.13)岁；体重20～40 kg， 平均(34.98±3.74)kg；

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